Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes.

@article{Xu1999EvidenceFI,
  title={Evidence for involvement of polymorphic CYP2C19 and 2C9 in the N-demethylation of sertraline in human liver microsomes.},
  author={Zhong Hua Xu and Wei Wang and Xue Jin Zhao and Shao-dan Huang and Bing Zhu and Nan Allen He and Yan Shu and Zhonghua Liu and Hong-Hao Zhou},
  journal={British journal of clinical pharmacology},
  year={1999},
  volume={48 3},
  pages={
          416-23
        }
}
AIMS The present study was designed to define the kinetic behaviour of sertraline N-demethylation in human liver microsomes and to identify the isoforms of cytochrome P450 involved in this metabolic pathway. METHODS The kinetics of the formation of N-demethylsertraline were determined in human liver microsomes from six genotyped CYP2C19 extensive (EM) and three poor metabolisers (PM). Selective inhibitors of and specific monoclonal antibodies to various cytochrome P450 isoforms were also… CONTINUE READING
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