Evidence for involvement of non-biliary excretion into the intestines in the formation of methylsulphonyl-containing metabolites of 2-chloro-N-isopropylacetanilide (propachlor) by swine and rats.

1. Radiolabelled metabolites excreted in the urine of swine after an oral dose of 14C-propachlor were similar to those previously reported with rats and included methylsulphonyl (CH3SO2-)-containing metabolites. 2. A bile-duct-cannulated pig dosed orally with 14C-propachlor excreted 7.6% dose in the bile compared with approx. 75% dose with rats. Although… CONTINUE READING