Evidence for involvement of cyclic nucleotides in intrinsic factor secretion by isolated rabbit gastric mucosa.

@article{Kapadia1979EvidenceFI,
  title={Evidence for involvement of cyclic nucleotides in intrinsic factor secretion by isolated rabbit gastric mucosa.},
  author={Cyrus R. Kapadia and David Eugene Schafer and Robert M. Donaldson and E. R. Ebersole},
  journal={The Journal of clinical investigation},
  year={1979},
  volume={64 4},
  pages={
          1044-9
        }
}
Secretion of intrinsic factor (IF) has previously been demonstrated in isolated rabbit fundic mucosa maintained in organ culture. We have now investigated the possibility that cyclic nucleotides may play a role in IF secretion. A phosphodiesterase inhibitor, 3-isobutyl methylxanthine (IBMX), stimulated IF secretion nearly fourfold while increasing tissue levels of both cyclic AMP (cAMP) and cyclic GMP (cGMP). Peak IF secretion in response to IBMX was not reached until after tissue cAMP levels… CONTINUE READING