Evidence for involvement of Wnt signaling pathway in IB-MECA mediated suppression of melanoma cells

@article{Fishman2002EvidenceFI,
  title={Evidence for involvement of Wnt signaling pathway in IB-MECA mediated suppression of melanoma cells},
  author={Pnina Fishman and Lea Madi and Sara Bar-Yehuda and Faina Barer and Luis Del Valle and Kamel Khalili},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={4060-4064}
}
The A3 adenosine receptor, A3AR, belongs to the family of Gi proteins, which upon induction, suppresses the formation of cAMP and its downstream effectors. Recent studies have indicated that activation of A3AR by its agonist, IB-MECA, results in growth inhibition of malignant cells. Here we demonstrate the ability of IB-MECA to decrease the levels of protein kinase A, a downstream effector of cAMP, and protein kinase B/Akt in melanoma cells. Examination of glycogen synthase kinase 3β, GSK-3… CONTINUE READING