Evidence for involvement of HMGB1 protein in human DNA mismatch repair.

  title={Evidence for involvement of HMGB1 protein in human DNA mismatch repair.},
  author={Fenghua Yuan and Liya Gu and Shuangli Guo and Chunmei Wang and Guo-Min Li},
  journal={The Journal of biological chemistry},
  volume={279 20},
Defects in human DNA mismatch repair predispose to cancer, but many components of the pathway have not been identified. We report here the identification and characterization of a novel component required for mismatch repair in human cells. A 30-kDa protein was purified to homogeneity by virtue of its ability to complement a depleted HeLa extract in repair of mismatched heteroduplexes. The complementing activity was identified as HMGB1 (the high mobility group box 1 protein), a non-histone… CONTINUE READING

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