Evidence for intracellular aggregation of hypericin and the impact on its photocytotoxicity in PAM 212 murine keratinocytes.

@article{Theodossiou2004EvidenceFI,
  title={Evidence for intracellular aggregation of hypericin and the impact on its photocytotoxicity in PAM 212 murine keratinocytes.},
  author={Theodossis A Theodossiou and Michael D Spiro and Jake H Jacobson and John Stephen Hothersall and Alexander J. Macrobert},
  journal={Photochemistry and photobiology},
  year={2004},
  volume={80 3},
  pages={438-43}
}
We have assessed photoinduced toxicity of hypericin in PAM 212 murine keratinocytes and the relationship between concentration, incubation time and light fluence to evaluate the effect of intracellular aggregation at high concentrations. Confocal microscopy was used to establish the subcellular localization of hypericin at 5 and 50 microM and incubation times of 1 and 3 h. From fluorescence uptake time course studies, intracellular hypericin was demonstrated to exist predominantly in the… CONTINUE READING

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