Evidence for interplay between genes and maternal stress in utero: monoamine oxidase A polymorphism moderates effects of life events during pregnancy on infant negative emotionality at 5 weeks.

@article{Hill2013EvidenceFI,
  title={Evidence for interplay between genes and maternal stress in utero: monoamine oxidase A polymorphism moderates effects of life events during pregnancy on infant negative emotionality at 5 weeks.},
  author={Jonathan Hill and Gerome Breen and John Quinn and Florin Tibu and Helen Sharp and Andrew Pickles},
  journal={Genes, brain, and behavior},
  year={2013},
  volume={12 4},
  pages={388-96}
}
The low activity variant of the monoamine oxidase A (MAOA) functional promoter polymorphism, MAOA-LPR, in interaction with adverse environments (G × E) is associated with child and adult antisocial behaviour disorders. MAOA is expressed during foetal development so in utero G × E may influence early neurodevelopment. We tested the hypothesis that MAOA G × E during pregnancy predicts infant negative emotionality soon after birth. In an epidemiological longitudinal study starting in pregnancy… CONTINUE READING
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