Evidence for intermolecular interaction as a necessary step for pore-formation activity and toxicity of Bacillus thuringiensis Cry1Ab toxin.

@article{Sobern2000EvidenceFI,
  title={Evidence for intermolecular interaction as a necessary step for pore-formation activity and toxicity of Bacillus thuringiensis Cry1Ab toxin.},
  author={Mario Sober{\'o}n and Richard V. Perez and Mar{\'i}a Eugenia Nu{\~n}ez-Valdez and Armida Gonz{\'a}lez Lorence and Isabel C G{\'o}mez and Jorge S{\'a}nchez and Alejandra Bravo},
  journal={FEMS microbiology letters},
  year={2000},
  volume={191 2},
  pages={221-5}
}
Based on the observation of large conductance states formed by Bacillus thuringiensis Cry toxins in synthetic planar lipid bilayers and the estimation of a pore size of 10-20 A, it has been proposed that the pore could be formed by an oligomer containing four to six Cry toxin monomers. However, there is a lack of information regarding the insertion of Cry toxins into the membrane and oligomer formation. Here we provide direct evidence showing that the intermolecular interaction between Cry1Ab… CONTINUE READING

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