Evidence for integrin receptor involvement in megakaryocyte-fibroblast interaction: a possible pathomechanism for the evolution of myelofibrosis.

@article{Schmitz1998EvidenceFI,
  title={Evidence for integrin receptor involvement in megakaryocyte-fibroblast interaction: a possible pathomechanism for the evolution of myelofibrosis.},
  author={Beate Schmitz and Juergen Thiele and Florian Otto and Patrick Farahmand and Frank Henze and Semra Frimpong and Claudia Wickenhauser and Randy H Fischer},
  journal={Journal of cellular physiology},
  year={1998},
  volume={176 3},
  pages={445-55}
}
Megakaryocytes are assumed to be functionally linked with the evolution of myelofibrosis, complicating chronic myeloproliferative disorders. It has already been shown that megakaryocytes will promote fibroblast growth in vitro when in spatial proximity. Here, we demonstrate that the integrin receptors alpha3beta1 and alpha5beta1 are involved in this megakaryocyte-fibroblast interaction. Upon addition of anti-alpha3 and -alpha5 antibodies to megakaryocyte-fibroblast cocultures, fibroblast growth… CONTINUE READING