Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic β-cell function and insulin secretion.

@article{Mckillop2009EvidenceFI,
  title={Evidence for inhibitory autocrine effects of proinsulin C-peptide on pancreatic β-cell function and insulin secretion.},
  author={A. M. Mckillop and Ming T. Ng and Yasser H. A. Abdel-Wahab and Peter Raymond Flatt},
  journal={Diabetes, obesity & metabolism},
  year={2009},
  volume={16 10},
  pages={
          937-46
        }
}
AIMS Autocrine and paracrine regulatory mechanisms ensure integrated secretion of islet hormones that respond efficiently to changes in metabolic need. As proinsulin C-peptide exerts various biological effects and binds to cell membranes including insulin-secreting β cells, its physiological role in insulin release was examined. METHODS Insulin releasing activity of human and rat C-peptides were studied in the clonal pancreatic cell line, BRIN-BD11, with findings substantiated using isolated… CONTINUE READING
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