Evidence for inhibition of fusion of lysosomal and prelysosomal compartments with phagosomes in macrophages infected with pathogenic Mycobacterium avium.

@article{Frhel1986EvidenceFI,
  title={Evidence for inhibition of fusion of lysosomal and prelysosomal compartments with phagosomes in macrophages infected with pathogenic Mycobacterium avium.},
  author={Claude Fr{\'e}hel and Chantal de Chastellier and Thierry Lang and Nalin Rastogi},
  journal={Infection and immunity},
  year={1986},
  volume={52 1},
  pages={252-62}
}
Bone marrow-derived cultured macrophages were infected with the pathogenic organism Mycobacterium avium. Immediately after infection and at 1 to 28 days later, cells either were stained for acid phosphatase activity or given horseradish peroxidase, which served as a pinocytotic marker. With the former, fusions between phagosomes and lysosomes exclusively were assessed; with the latter, those between phagosomes and both pinosomes and lysosomes were determined. As a control, similar experiments… CONTINUE READING

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