Evidence for ineffective erythropoiesis in severe sickle cell disease.

  title={Evidence for ineffective erythropoiesis in severe sickle cell disease.},
  author={Catherine J. Wu and Lakshamanan Krishnamurti and Jeffery L. Kutok and Melinda A Biernacki and Shelby A Rogers and Wandi Zhang and Joseph H Antin and Jerome Ritz},
  volume={106 10},
Peripheral destruction of sickled erythrocytes is a cardinal feature of sickle cell disease (SCD). Less well established is the potential contribution of ineffective erythropoiesis to the pathophysiology of this hemoglobinopathy. Since patients with SCD frequently develop mixed hematopoietic chimerism after allogeneic nonmyeloablative stem cell transplantation, we used this opportunity to directly compare the differentiation and survival of SCD and donor-derived erythropoiesis in vivo. Donor… CONTINUE READING


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