Evidence for increased seizure susceptibility in rats exposed to cocaine in utero.

@article{Baraban1997EvidenceFI,
  title={Evidence for increased seizure susceptibility in rats exposed to cocaine in utero.},
  author={Scott C Baraban and Eoghan McCarthy and Philip A. Schwartzkroin},
  journal={Brain research. Developmental brain research},
  year={1997},
  volume={102 2},
  pages={189-96}
}
Clinical observations indicate that cocaine use during pregnancy is a major health concern in the United States and may result in seizure-like behavior in the offspring. In the present study, we investigated whether prenatal cocaine exposure altered seizure thresholds measured in Sprague-Dawley rats, 60-90 days postnatal. In vitro postnatal studies, focusing on hippocampal tissue, revealed a reduced threshold for both electrical stimulation- and potassium-induced epileptiform discharges in… CONTINUE READING

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