Evidence for increased myofibrillar mobility in desmin-null mouse skeletal muscle.

@article{Shah2002EvidenceFI,
  title={Evidence for increased myofibrillar mobility in desmin-null mouse skeletal muscle.},
  author={Sameer B. Shah and Fong-Chin Su and Kimberly A. Jordan and Derek J. Milner and Jan Frid{\'e}n and Yassemi Capetanaki and Richard L Lieber},
  journal={The Journal of experimental biology},
  year={2002},
  volume={205 Pt 3},
  pages={321-5}
}
Quantitative electron microscopy was used to characterize the longitudinal mobility of myofibrils during muscle extension to investigate the functional roles of skeletal muscle intermediate filaments. Extensor digitorum longus fifth toe muscles from wild-type (+/+) and desmin-null (des -/-) animals were passively stretched to varying lengths, and the horizontal displacement of adjacent Z-disks in neighboring myofibrils (Deltax(myo)) and average sarcomere length (SL) were calculated. At short SL… CONTINUE READING