Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA.

@article{Hino1991EvidenceFI,
  title={Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA.},
  author={Okio Hino and Satoshi Tabata and Yasuo Hotta},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 20},
  pages={9248-52}
}
Chromosomal translocation, deletion, and inversion/duplication directly linked to hepatitis B virus (HBV) DNA integration occur frequently in host DNA of human hepatocellular carcinomas. To test the possible recombinogenic effect of HBV DNA, we have utilized an in vitro recombination assay. Fragments containing the region spanning DR1, which is believed to be the origin of viral replication and a preferred site in the viral genome for integration, increased the recombination events reproducibly… CONTINUE READING

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