Evidence for increased glutamatergic cortical facilitation in children and adolescents with major depressive disorder.

@article{Croarkin2013EvidenceFI,
  title={Evidence for increased glutamatergic cortical facilitation in children and adolescents with major depressive disorder.},
  author={Paul E. Croarkin and Paul A. Nakonezny and Mustafa M. Husain and Tabatha H Melton and Jeylan S Buyukdura and Betsy D. Kennard and Graham J. Emslie and F. Andrew Kozel and Zafiris Jeff Daskalakis},
  journal={JAMA psychiatry},
  year={2013},
  volume={70 3},
  pages={291-9}
}
CONTEXT Converging lines of evidence implicate the glutamate and γ-aminobutyric acid neurotransmitter systems in the pathophysiology of major depressive disorder. Transcranial magnetic stimulation cortical excitability and inhibition paradigms have been used to assess cortical glutamatergic and γ-aminobutyric acid-mediated tone in adults with major depressive disorder, but not in children and adolescents. OBJECTIVE To compare measures of cortical excitability and inhibition with 4 different… CONTINUE READING

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