Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.

@article{Berman2000EvidenceFI,
  title={Evidence for increased dorsal hippocampal adenosine release and metabolism during pharmacologically induced seizures in rats.},
  author={Robert F. Berman and Bertil B. Fredholm and Ulrika {\AA}d{\'e}n and W. T. O'Connor},
  journal={Brain research},
  year={2000},
  volume={872 1-2},
  pages={44-53}
}
There is growing pharmacological evidence from several animal models of seizure disorder that adenosine possesses endogenous anticonvulsant activity. In order to further evaluate the role of adenosine in seizure activity, we monitored adenosine and its major biochemical metabolites inosine, xanthine, and hypoxanthine in the dorsal hippocampus by in vivo microdialysis before and during the induction of generalized seizures. Seizures were induced pharmacologically in groups of urethane… CONTINUE READING