Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques.

@article{Sukhova1999EvidenceFI,
  title={Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques.},
  author={Galina K Sukhova and Uwe Schoenbeck and Elena Rabkin and Frederick J. Schoen and Anthony Poole and R. Clark Billinghurst and P. Scott Libby},
  journal={Circulation},
  year={1999},
  volume={99 19},
  pages={2503-9}
}
BACKGROUND Several recent studies attempted to classify plaques as those prone to cause clinical manifestations (vulnerable, atheromatous plaques) or those less frequently associated with acute thrombotic complication (stable, fibrous plaques). Defining the cellular and molecular mechanisms that underlie these morphological features remains a challenge. Because interstitial forms of collagen determine the biomechanical strength of the atherosclerotic lesion, this study investigated expression… CONTINUE READING
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