Evidence for in vivo peroxynitrite production in human acute lung injury.

  title={Evidence for in vivo peroxynitrite production in human acute lung injury.},
  author={Neil W. Kooy and James A. Royall and Y Z Ye and David R. Kelly and Joseph S. Beckman},
  journal={American journal of respiratory and critical care medicine},
  volume={151 4},
Oxidant-mediated toxicity resulting from acute pulmonary inflammation has been demonstrated in acute lung injury. A potent biological oxidant, peroxynitrite, is formed by the near diffusion-limited reaction of nitric oxide with superoxide. In addition to having hydroxyl radical-like oxidative reactivity, peroxynitrite is capable of nitrating phenolic rings, including protein-associated tyrosine residues. Nitric oxide does not directly nitrate tyrosine residues, therefore, demonstration of… Expand
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