Evidence for in vivo internalization of human leukocyte elastase by alveolar macrophages.

@article{White1982EvidenceFI,
  title={Evidence for in vivo internalization of human leukocyte elastase by alveolar macrophages.},
  author={Roger F. White and Aaron Janoff and Re Gordon and EdwardJ. Campbell},
  journal={The American review of respiratory disease},
  year={1982},
  volume={125 6},
  pages={
          779-81
        }
}
Cell lysates from cultured human alveolar macrophages contain detectable amounts of an elastinolytic enzyme. Although particulate elastin was solubilized only after prolonged incubations, lysates readily hydrolyzed T-OC-alanyl-p-nitrophenol-ester. Hydrolysis of the latter substrate was inhibited by the leukocyte elastase site-specific inhibitor, N-ac-(ala)4-chloromethyl ketone. In addition, radioimmunoelectrophoresis of concentrated alveolar macrophage lysates, previously incubated with 3H… CONTINUE READING
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