Evidence for improved performance in cognitive tasks following selective NR2B NMDA receptor antagonist pre-treatment in the rat

@article{Higgins2005EvidenceFI,
  title={Evidence for improved performance in cognitive tasks following selective NR2B NMDA receptor antagonist pre-treatment in the rat},
  author={Guy A Higgins and Theresa Maria Ballard and Michel Enderlin and Marie Haman and John A. Kemp},
  journal={Psychopharmacology},
  year={2005},
  volume={179},
  pages={85-98}
}
We previously reported that the NR2B subunit-selective N-methyl-d-aspartate (NMDA) antagonist Ro 63-1908 produced a marked deficit in response control in the five-choice serial reaction time task (5-CSRTT). The present studies were designed to investigate this further by studying the NR2B NMDA antagonists, ifenprodil, traxoprodil (CP101,606), Ro 25-6981 as well as Ro 63-1908 in this test. Following training in the 5-CSRTT, separate groups of rats were either tested under (1) standard test… CONTINUE READING
26 Citations
78 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 78 references

Pharmacological characterisation of Ro 63-1908, a novel sub-type selective NMDA antagonist

  • R Gill, A Alanine, +16 authors JA Kemp
  • J Pharmacol Exp Ther
  • 2002
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…