Evidence for high affinity [3H] imipramine binding sites in human lung.

@article{Morin1984EvidenceFH,
  title={Evidence for high affinity [3H] imipramine binding sites in human lung.},
  author={Didier Morin and Roland Zini and J Lange and Jean Paul Tillement},
  journal={Biochemical and biophysical research communications},
  year={1984},
  volume={120 3},
  pages={
          926-32
        }
}
[3H] imipramine exhibits both saturable and high affinity binding sites in human lung with a maximal number of binding sites of 7.50 pmoles/mg protein and a dissociation constant of 1.74 nM. Displacement studies indicate that these sites can be considered as specific of imipramine, tricyclic compounds and also monoamine uptake inhibitors:fluoxetine and nisoxetine. Atypical antidepressants were inactive as ligands of main known receptors. 

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