Evidence for heterogeneity in recombination in the human pseudoautosomal region: high resolution analysis by sperm typing and radiation-hybrid mapping.

@article{Lien2000EvidenceFH,
  title={Evidence for heterogeneity in recombination in the human pseudoautosomal region: high resolution analysis by sperm typing and radiation-hybrid mapping.},
  author={Sigbj\orn Lien and Joanna Szyda and Birgit Schechinger and Gudrun A Rappold and Norman Arnheim},
  journal={American journal of human genetics},
  year={2000},
  volume={66 2},
  pages={557-66}
}
Accurate genetic and physical maps for the human pseudoautosomal region were constructed by use of sperm typing and high-resolution radiation-hybrid mapping. PCR analysis of 1,912 sperm was done with a manual, single-sperm isolation method. Data on four donors show highly significant linkage heterogeneity among individuals. The most significant difference was observed in a marker interval located in the middle of the Xp/Yp pseudoautosomal region, where one donor showed a particularly high… CONTINUE READING