Evidence for hepatocarcinogenic activity of pentachlorobenzene with intralobular variation in foci incidence.

@article{Thomas1998EvidenceFH,
  title={Evidence for hepatocarcinogenic activity of pentachlorobenzene with intralobular variation in foci incidence.},
  author={Russell S. Thomas and Daniel L. Gustafson and W A Pott and Michael E. Long and Stephen A. Benjamin and Raymond S. H. Yang},
  journal={Carcinogenesis},
  year={1998},
  volume={19 10},
  pages={
          1855-62
        }
}
Pentachlorobenzene (PeCB) is an important environmental contaminant derived primarily from the by-product contamination of the popular fungicides hexachlorobenzene and pentachloronitrobenzene. Its tumor-promoting activity was studied in a medium-term initiation/promotion assay in male F344 rats. Animals were given a single i.p. injection of diethylnitrosamine (200 mg/kg body weight) and 2 weeks later were administered 0.1 or 0.4 mmol/kg per day PeCB by gavage in a corn oil vehicle, 7 days/week… CONTINUE READING
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