• DOI:10.1038/ng775
Corpus ID: 20262212

Evidence for genomic rearrangements mediated by human endogenous retroviruses during primate evolution

@article{Hughes2001EvidenceFG,
  title={Evidence for genomic rearrangements mediated by human endogenous retroviruses during primate evolution},
  author={J. Hughes and J. Coffin},
  journal={Nature Genetics},
  year={2001},
  volume={29},
  pages={487-489}
}

J. Hughes, J. Coffin

Published 2001

Biology, Medicine

Nature Genetics

Human endogenous retroviruses (HERVs), which are remnants of past retroviral infections of the germline cells of our ancestors, make up as much as 8% of the human genome and may even outnumber genes. Most HERVs seem to have entered the genome between 10 and 50 million years ago, and they comprise over 200 distinct groups and subgroups. Although repeated sequence elements such as HERVs have the potential to lead to chromosomal rearrangement through homologous recombination between distant loci… CONTINUE READING

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