Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins.

  title={Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins.},
  author={Dorit Carmelli and Charles DeCarli and Gary E. Swan and Lisa M. Jack and Terry Reed and Philip A. Wolf and Bruce L. Miller},
  volume={29 6},
BACKGROUND AND PURPOSE White matter hyperintensities (WMHs), as detected by MRI, are common among the elderly and are frequently interpreted as representing a subclinical form of ischemic brain damage. We used volumetric MR techniques to investigate the contribution of genes and the environment to measures of brain morphology in a sample of community dwelling elderly male twins. METHODS Brain MR (1.5 T) scans were obtained from 74 monozygotic (MZ) and 71 dizygotic (DZ), white, male, World War… CONTINUE READING
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