Evidence for gender differences in electrophysiological properties of canine Purkinje fibres

@article{AbiGerges2004EvidenceFG,
  title={Evidence for gender differences in electrophysiological properties of canine Purkinje fibres},
  author={Najah Abi-Gerges and Ben G Small and Chris L Lawrence and Tim G. Hammond and J.-P. Valentin and Chris E Pollard},
  journal={British Journal of Pharmacology},
  year={2004},
  volume={142}
}
Women are more prone to develop torsades de pointes, a rare life‐threatening polymorphic ventricular tachycardia, than are men during administration of medicines that have the potential to block IKr (rapid delayed rectifier cardiac K+ current) and to prolong the QT interval. Blockade of IKr, hypokalaemia and extreme bradycardia were used to evaluate whether there are gender differences in cardiac repolarisation in canine Purkinje fibres (PFs). Microelectrode techniques were employed to measure… Expand
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