Evidence for gamma-MSH-like immunoreactivity in ectopic ACTH-producing tumors.


Using a specific radioimmunoassay for gamma-MSH, a predicted peptide in the cryptic N-terminal portion of the adrenocorticotropin-beta-lipotropin precursor, gamma-MSH-like immunoreactivity (gamma-MLI) was detected in two ectopic ACTH producing tumors. Gel chromatographic studies on Bio-Gel P-60 revealed one or two peaks of gamma-MLI; one was eluted near th elution position of beta-LPH, compatible with gamma-MLI in human pituitary and the other emerged near the position of beta-endorphin. These results indicate that ectopic ACTH-producing tumors eleborate not only ACTH, beta-endorphin but also gamma-MLI.

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@article{Nakai1980EvidenceFG, title={Evidence for gamma-MSH-like immunoreactivity in ectopic ACTH-producing tumors.}, author={Yoshiaki Nakai and Isamu Tanaka and Junichi Fukata and Kazuwa Nakao and Shogo Oki and Shinji Takai and Hiroo Imura}, journal={The Journal of clinical endocrinology and metabolism}, year={1980}, volume={50 6}, pages={1147-8} }