Evidence for fusion between cardiac and skeletal muscle cells.

@article{Reinecke2004EvidenceFF,
  title={Evidence for fusion between cardiac and skeletal muscle cells.},
  author={Hans J{\"u}rgen Reinecke and Elina Minami and Veronica Poppa and Charles E Murry},
  journal={Circulation research},
  year={2004},
  volume={94 6},
  pages={
          e56-60
        }
}
Cardiomyoplasty with skeletal myoblasts may benefit cardiac function after infarction. Recent reports indicate that adult stem cells can fuse with other cell types. Because myoblasts are "fusigenic" cells by nature, we hypothesized they might be particularly likely to fuse with cardiomyocytes. To test this, neonatal rat cardiomyocytes labeled with LacZ and green fluorescent protein (GFP) were cocultured with unlabeled C2C12 myoblasts. After 3 days, we observed a small population of skeletal… CONTINUE READING

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Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response.

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