Evidence for functional release of endogenous opioids in the locus ceruleus during stress termination.

@article{Curtis2001EvidenceFF,
  title={Evidence for functional release of endogenous opioids in the locus ceruleus during stress termination.},
  author={Andre L. Curtis and Nicholas T. Bello and Rita J Valentino},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 13},
  pages={RC152}
}
Endogenous opioids target noradrenergic locus ceruleus (LC) neurons and potently inhibit LC activity. Nonetheless, it has been difficult to demonstrate functional regulation of the LC-noradrenergic system by endogenous opioids because of the lack of effect of opiate antagonists. The present findings provide evidence that endogenous opioids regulate LC neuronal activity during the termination of a stressor. LC neuronal discharge was recorded from halothane-anesthetized rats before, during, and… CONTINUE READING