Evidence for functional importance of usherin/fibronectin interactions in retinal basement membranes.

@article{Bhattacharya2005EvidenceFF,
  title={Evidence for functional importance of usherin/fibronectin interactions in retinal basement membranes.},
  author={Gautam Bhattacharya and Dominic Cosgrove},
  journal={Biochemistry},
  year={2005},
  volume={44 34},
  pages={11518-24}
}
Usher syndrome is a genetically heterogeneous disorder characterized by hearing loss with retinitis pigmentosa. Usher syndrome type IIa is the most common of the Usher syndromes, accounting for over half of all cases. The gene encodes a 180 kDa basement membrane glycoprotein called usherin. Here, we demonstrated a specific interaction between usherin and fibronectin in retinal basement membranes. This interaction was confirmed using biochemical, biophysical, and genetic approaches. Surface… CONTINUE READING