Evidence for functional expression of TRPM7 channels in human atrial myocytes

  title={Evidence for functional expression of TRPM7 channels in human atrial myocytes},
  author={Yan-hui Zhang and Hai-Ying Sun and Kui-Hao Chen and Xin-ling Du and Bo Liu and Lik-cheung Cheng and Xin Li and Man-wen Jin and Gui-Rong Li},
  booktitle={Basic Research in Cardiology},
Transient receptor potential melastatin-7 (TRPM7) channels have been recently reported in human atrial fibroblasts and are believed to mediate fibrogenesis in human atrial fibrillation. The present study investigates whether TRPM7 channels are expressed in human atrial myocytes using whole-cell patch voltage-clamp, RT-PCR and Western blotting analysis. It was found that a gradually activated TRPM7-like current was recorded with a K+- and Mg2+-free pipette solution in human atrial myocytes. The… CONTINUE READING


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