Evidence for functional differentiation among Drosophila septins in cytokinesis and cellularization.

@article{Adam2000EvidenceFF,
  title={Evidence for functional differentiation among Drosophila septins in cytokinesis and cellularization.},
  author={Jennifer C. Adam and John R. Pringle and Mark Peifer},
  journal={Molecular biology of the cell},
  year={2000},
  volume={11 9},
  pages={
          3123-35
        }
}
The septins are a conserved family of proteins that are involved in cytokinesis and other aspects of cell-surface organization. In Drosophila melanogaster, null mutations in the pnut septin gene are recessive lethal, but homozygous pnut mutants complete embryogenesis and survive until the pupal stage. Because the completion of cellularization and other aspects of early development seemed likely to be due to maternally contributed Pnut product, we attempted to generate embryos lacking the… CONTINUE READING
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