Corpus ID: 9123252

Evidence for free radical scavenging activity of Ashwagandha root powder in mice.

@article{Panda1997EvidenceFF,
  title={Evidence for free radical scavenging activity of Ashwagandha root powder in mice.},
  author={Sunanda Panda and Anand Kar},
  journal={Indian journal of physiology and pharmacology},
  year={1997},
  volume={41 4},
  pages={
          424-6
        }
}
  • S. Panda, A. Kar
  • Published 1997
  • Chemistry, Medicine
  • Indian journal of physiology and pharmacology
The effects of Ashwagandha root powder (0.7 and 1.4 g/kg body weight/day), administered for 15 and 30 days, was investigated on lipid peroxidation (LPO), superoxide dismutase (SOD) and catalase (CAT) activities in mice. While 15 days treatment with Ashwagandha root powder did not produce any significant change, 30 days treatment produced a significant decrease in LPO, and an increase in both SOD and CAT. Our findings indicate that Ashwagandha root powder possesses free radical scavenging… Expand
Withania somnifera root extract in the regulation of lead-induced oxidative damage in male mouse.
TLDR
It is suggested that the ameliorating role of root extract of W. somnifera in the lead intoxicated mice could be the result of its antiperoxidative action. Expand
Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha.
  • K. Kaur, G. Rani, +4 authors R. Wadhwa
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2004
TLDR
It is found that the Lash from field-raised plants has a significant anti-proliferative activity in human tumorigenic cells, but it did not impart any protection against the oxidative damage caused by high glucose and hydrogen peroxide to human tumor cells suggesting that it can be used as an anti-tumor, but not as anAnti-oxidant, substance. Expand
Glioprotective Effects of Ashwagandha Leaf Extract against Lead Induced Toxicity
TLDR
It is suggested that Ashwagandha water extract may have the potential therapeutic implication against lead poisoning. Expand
Hepatoprotective effects of Allium sativum and Withania somnifera on ochratoxin A-induced toxicity in rats
Withania somnifera and Allium sativum are the traditional medicinal plants used to improve the liver functions. Since, oxidative stress promotes the ochratoxin A (OTA)-induced hepatotoxicity, weExpand
PHARMACOGNOSTIC AND FREE-RADICAL SCAVENGING ACTIVITY INTHE DIFFERENT PARTS OF ASHWAGANDHA [Withania somnifera (L.Dunal)]
TLDR
The observations from this study suggest the ethno-medicinal use of Ashwagandha which could be commercially exploited by the pharmaceutical industry for natural antioxidant. Expand
In vivo, effect of herb (Withania somnifera) on immunomodulatory and antioxidative potential of milk in mice
TLDR
Findings indicated that aqueous extract of WS is able to enhance immunomodulatory and antioxidative properties of milk. Expand
Effect of Withania somnifera root extract on lead-induced DNA damage
Protective effect of Withania somnifera against formation of micronuclei induced by lead nitrate in bone marrow cells of mice was studied. Administration of lead nitrate (40 mg/kg b.w) inducedExpand
The neuroprotective effect of Withania somnifera root extract in MPTP-intoxicated mice: An analysis of behavioral and biochemical varibles
TLDR
Oral treatment with the root extract resulted in a significant improvement in the mice’s behavoiur and antioxidant status, along with a significant reduction in the level of lipid peroxidation, which indicated that at least part of the chronic stress-induced pathology may be due to oxidative stress, which is mitigated by Ws. Expand
FREE RADICAL SCAVENGING ACTIVITY OF SIX MEDICINAL PLANTS OF BANGLADESH: APOTENTIAL SOURCE OF NATURAL ANTIOXIDANT
TLDR
The crude meoh extracts of six medicinal plants of bangladesh were screened for primary types of phytochemicals presence and in-vitro anti-oxidant activity by using the 1,1-diphenyl-2-picryldydrazylhydrate (dpph) free radical scavenging assay. Expand
The induction of human superoxide dismutase and catalase in vivo: a fundamentally new approach to antioxidant therapy.
TLDR
Modest induction of the catalytic antioxidants SOD and catalase may be a much more effective approach than supplementation with antioxidants that can, at best, stoichiometrically scavenge a very small fraction of total oxidant production. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
Protective effect of Rubia cordifolia on lipid peroxide formation in isolated rat liver homogenate.
TLDR
The anti-peroxidative property of the solvent free alcoholic extract of R. cordifolia has been studied in rat liver homogenate and prevents the cumene hydroperoxide induced malondialdehyde formation in the dose and time dependent manner. Expand
Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine.
TLDR
The iron chelator desferrioxamine inhibits peroxidation at all concentrations tested, and it also inhibits the iron-catalysed formation of hydroxyl radicals from superoxide (O2-.). Expand
Bacopa monniera Linn. as an antioxidant: mechanism of action.
TLDR
Brahmi only slightly protected the autooxidation and FeSO4 induced oxidation of reduced glutathione on lower doses 100 micrograms/ml and below, but on higher concentrations it enhanced the rate of oxidation. Expand
Loss of membrane integrity and inhibition of type-I iodothyronine 5'-monodeiodinase activity by fenvalerate in female mouse.
TLDR
A marginal increase in T4 concentration in highest dose-treated group compared to that of the lower one supports the view that the monodeiodination of the phenolic ring of T4 is inhibited by fenvalerate. Expand
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.
TLDR
Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content. Expand
Free radical mediated membrane perturbation and inhibition of type‐I iodothyronine 5′‐monodeiodinase activity by lead and cadmium in rat liver homogenate
TLDR
Since LPO is primarily an outcome of free radical generation, it is suggested metal induced free radical mediated inhibition of 5′‐D activity in rat liver homogenate is suggested. Expand
Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase.
TLDR
The autoxidation of pyrogallol was investigated in the presence of EDTA in the pH range 7.9–10.6, indicating an almost total dependence on the participation of the superoxide anion radical, O2·−, in the reaction. Expand
Bocopa mon/uua Linn. all an antioxidant: Me<:hanilm of action
  • Indian J E"p BIoi
  • 1996
Ashwagandha (Withania somnifera): A Itatul report
  • J Med Arom Plant Science
  • 1996
Ashwagandha (Withania sornnifer a): A status report
  • J Med Arom Plant Science
  • 1996
...
1
2
...