Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire

@article{Parker1990EvidenceFE,
  title={Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire},
  author={Christina M. Parker and Veronika Groh and Hamid Band and Steven A. Porcelli and Chika Morita and Marina Fabbi and David Glass and Jack Leonard Strominger and Michael B Brenner},
  journal={The Journal of Experimental Medicine},
  year={1990},
  volume={171},
  pages={1597 - 1612}
}
The germline repertoire of variable genes for the TCR-gamma/delta is limited. This, together with the availability of several V delta-specific and a C delta-specific mAbs, has made it possible to assess differences in the TCR-gamma/delta repertoire in man. TCR-gamma/delta cells expressing particular V gene segments have been previously shown to be localized in different anatomical sites. In this study, analysis of TCR-gamma/delta V gene segment usage performed on subjects from the time of birth… CONTINUE READING

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