Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire

  title={Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire},
  author={C. Parker and V. Groh and H. Band and S. A. Porcelli and C. Morita and M. Fabbi and D. Glass and J. Strominger and M. Brenner},
  journal={The Journal of Experimental Medicine},
  pages={1597 - 1612}
  • C. Parker, V. Groh, +6 authors M. Brenner
  • Published 1990
  • Medicine, Biology
  • The Journal of Experimental Medicine
  • The germline repertoire of variable genes for the TCR-gamma/delta is limited. This, together with the availability of several V delta- specific and a C delta-specific mAbs, has made it possible to assess differences in the TCR-gamma/delta repertoire in man. TCR-gamma/delta cells expressing particular V gene segments have been previously shown to be localized in different anatomical sites. In this study, analysis of TCR-gamma/delta V gene segment usage performed on subjects from the time of… CONTINUE READING
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