Evidence for extensive methylation of ribosomal RNA genes in a rat XC cell line.

@article{Katz1983EvidenceFE,
  title={Evidence for extensive methylation of ribosomal RNA genes in a rat XC cell line.},
  author={Richard A. Katz and Bernard F. Erlanger and Ramareddy V. Guntaka},
  journal={Biochimica et biophysica acta},
  year={1983},
  volume={739 3},
  pages={258-64}
}
XC cell line was established from a rat fibrosarcoma induced by avian sarcoma virus. Analysis of ribosomal RNA genes in the DNA of this cell line indicated that there was a 3- to 4-fold increase in the number of the rDNA repeating units. [methyl-14C]Methionine labeling experiments as well as Southern blot analysis of the restriction endonuclease fragments showed extensive methylation of the cytosine residues in the rDNA. Further analysis by HpaII, HhaI and MspI suggested that the entire rDNA… CONTINUE READING

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