• DOI:10.1677/JOE.0.127R005
Corpus ID: 34320534

Evidence for extended maintenance of the corpus luteum by uterine infusion of a recombinant trophoblast alpha-interferon (trophoblastin) in sheep.

@article{Martal1990EvidenceFE,
  title={Evidence for extended maintenance of the corpus luteum by uterine infusion of a recombinant trophoblast alpha-interferon (trophoblastin) in sheep.},
  author={J. Martal and E. Degryse and G. Charpigny and N. Assal and P. Reinaud and M. Charlier and P. Gaye and J. Lecocq},
  journal={The Journal of endocrinology},
  year={1990},
  volume={127 3},
  pages={
          R5-8
        }
}

J. Martal, E. Degryse, +5 authors J. Lecocq

Published 1990

Biology, Medicine

The Journal of endocrinology

Ovine trophoblastin (oTP) is a natural interferon of the class-II interferon-alpha subfamily. Recombinant ovine trophoblastin (r.oTP), produced by genetic engineering, was purified by anion-exchange HPLC. The product exhibited a high degree of homogeneity (greater than 98%), and similar immunological cross reaction and antiviral activity to natural oTP. Antiluteolytic activity of r.oTP was established by intrauterine injection in two groups of cyclic recipient ewes. Control group A included 10… CONTINUE READING

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