Evidence for epithelial-mesenchymal interactions mediating glucocorticoid effects in developing chick liver

Abstract

When trypsin-dissociated liver cells from 17-day chick embryos were grown in regular minimum essential medium, mixed hepatocyte-fibroblast cultures resulted. When D-valine was substituted for L-valine in this medium, fibroblast growth was suppressed, leaving virtually pure hepatocyte cultures. Tyrosine aminotransferase activity is induced by cortisol in… (More)
DOI: 10.1007/BF00215776

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