Evidence for efficient vertical transfer of maternal HIV-1 envelope-specific neutralizing antibodies but no association of such antibodies with reduced infant infection.

Abstract

: Little is known about the efficiency of vertical transfer of HIV-1-specific antibodies. Antibody levels in plasma from 60 mother-infant pairs near the time of birth, including 14 breast-feeding transmission pairs, were compared. The envelope-binding titers were strongly correlated (r = 0.91, P < 0.0001) and similar (1.4-fold greater in maternal plasma) between a mother and her corresponding infant as were the neutralizing antibody (Nab) levels (r = 0.80, P < 0.0001; 1.3-fold higher), suggesting efficient transfer. There was no significant difference in Nab responses between transmitting and nontransmitting mothers, although there was a trend for transmitting mothers to have higher HIV-1-specific Nabs.

DOI: 10.1097/QAI.0b013e31829f6e41

Cite this paper

@article{Omenda2013EvidenceFE, title={Evidence for efficient vertical transfer of maternal HIV-1 envelope-specific neutralizing antibodies but no association of such antibodies with reduced infant infection.}, author={Maxwel M. Omenda and Caitlin Milligan and Katherine S Odem-Davis and Ruth Nduati and Barbra Ann Richardson and John B. Lynch and Grace John-Stewart and Julie M Overbaugh}, journal={Journal of acquired immune deficiency syndromes}, year={2013}, volume={64 2}, pages={163-6} }