Evidence for ecto-protein kinase activity on the surface of human neutrophils.

@article{Dusenbery1988EvidenceFE,
  title={Evidence for ecto-protein kinase activity on the surface of human neutrophils.},
  author={Kathryn E. Dusenbery and John R. Mendiola and Keith M Skubitz},
  journal={Biochemical and biophysical research communications},
  year={1988},
  volume={153 1},
  pages={
          7-13
        }
}
Recent studies have suggested a possible role for extracellular ATP in neutrophil function. This report provides evidence for the existence of an ecto-protein kinase activity on the surface of human neutrophils capable of phosphorylating intrinsic cell membrane proteins as well as exogenous proteins. Addition of extracellular [gamma-32P]ATP to neutrophils resulted in rapid incorporation of 32P into cellular proteins that were sensitive to trypsin. The ability of adherent cells to phosphorylate… CONTINUE READING

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