Evidence for down-regulation of GAP-43 mRNA in Wobbler mouse spinal motoneurons by corticosterone and a 21-aminosteroid.

@article{Deniselle1999EvidenceFD,
  title={Evidence for down-regulation of GAP-43 mRNA in Wobbler mouse spinal motoneurons by corticosterone and a 21-aminosteroid.},
  author={Mar{\'i}a Claudia Gonz{\'a}lez Deniselle and Claudia Alejandra Grillo and Sara Gonzalez and Paulina Roig and Alejandro Federico De Nicola},
  journal={Brain research},
  year={1999},
  volume={841 1-2},
  pages={78-84}
}
Expression of the growth-associated protein GAP-43 is increased in the spinal cord of ALS patients and Wobbler (wr) mice, murine models of the disease. In this work we examined if expression of GAP-43 mRNA in control and wr mice was sensitive to steroid treatment. A group of control and wr mice received s.c. a 50 mg pellet of the natural hormone corticosterone (CORT) or the antioxidant 21-aminosteroid U-74389F during 4 days. Basal levels of GAP-43 mRNA were 10-fold elevated in ventral horn… CONTINUE READING

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