Evidence for displacements of the C-helix by CO ligation and DNA binding to CooA revealed by UV resonance Raman spectroscopy.

@article{Kubo2006EvidenceFD,
  title={Evidence for displacements of the C-helix by CO ligation and DNA binding to CooA revealed by UV resonance Raman spectroscopy.},
  author={Minoru Kubo and Sayaka Inagaki and Shiro Yoshioka and Takeshi Uchida and Yasuhisa Mizutani and Shigetoshi Aono and Teizo Kitagawa},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 16},
  pages={11271-8}
}
The UV and visible resonance Raman spectra are reported for CooA from Rhodospirillum rubrum, which is a transcriptional regulator activated by growth in a CO atmosphere. CO binding to heme in its sensor domain causes rearrangement of its DNA-binding domain, allowing binding of DNA with a specific sequence. The sensor and DNA-binding domains are linked by a… CONTINUE READING