Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current.

@article{Liao2001EvidenceFD,
  title={Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current.},
  author={Gene Y. Liao and David A. Wagner and M H Hsu and John P. Leonard},
  journal={Molecular pharmacology},
  year={2001},
  volume={59 5},
  pages={960-4}
}
Protein kinase-C (PKC) activation differentially affects currents from N-methyl-D-aspartate (NMDA) type glutamate receptors depending upon their subunit composition. Experiments using chimeras initially indicated that the cytoplasmic C-terminal tails of NR2B (responsive to PKC) and NR2C (unresponsive to PKC) subunits contain the amino acid residues responsible for the observed disparity of PKC effects. However, truncation and point mutation experiments have suggested that PKC action on NMDA… CONTINUE READING
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