Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose- and calcium-induced insulin secretion from pancreatic beta cells.

@article{Kowluru1997EvidenceFD,
  title={Evidence for differential roles of the Rho subfamily of GTP-binding proteins in glucose- and calcium-induced insulin secretion from pancreatic beta cells.},
  author={Anjaneyulu Kowluru and Guodong Li and Mary E. Rabaglia and Venkatesh Babu Segu and Fred Hofmann and Klaus Aktories and Stewart A Metz},
  journal={Biochemical pharmacology},
  year={1997},
  volume={54 10},
  pages={1097-108}
}
We utilized clostridial toxins (with known specificities for inhibition of GTPases) to ascertain the contribution of candidate GTPases in physiologic insulin secretion from beta cells. Exposure of normal rat islets or isolated beta (HIT-T15) cells to Clostridium difficile toxins A and B catalyzed the glucosylation (and thereby the inactivation) of Rac, Cdc42, and Rho endogenous to beta cells; concomitantly, either toxin reduced glucose- or potassium-induced insulin secretion from rat islets and… CONTINUE READING
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