Evidence for differential post-translational modifications of slow myosin heavy chain during murine skeletal muscle development

@article{Maggs2000EvidenceFD,
  title={Evidence for differential post-translational modifications of slow myosin heavy chain during murine skeletal muscle development},
  author={Alison M. Maggs and Pamela M. Taylor-Harris and Michelle Peckham and Stephanie M. Hughes},
  journal={Journal of Muscle Research & Cell Motility},
  year={2000},
  volume={21},
  pages={101-113}
}
The contractile properties of muscle fibres are, in part, determined by the myosin heavy chain (MyHC) isoforms they express. Using monoclonal antibodies, we show that at least three forms of slow twitch MyHC accumulate sequentially during mouse fetal development and that slow MyHC maturation in slow fibres occurs before expression of the adult fast MyHCs in fast fibres. Expression of deletion derivatives of β-cardiac MyHC cDNA shows that the slow MyHC epitopes that are detected in adult but not… CONTINUE READING

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