Evidence for different exocytosis pathways in dendritic and terminal dopamine release in vivo.

@article{Bergquist2002EvidenceFD,
  title={Evidence for different exocytosis pathways in dendritic and terminal dopamine release in vivo.},
  author={Filip Bergquist and Haydeh Shahabi Niazi and Hans Nissbrandt},
  journal={Brain research},
  year={2002},
  volume={950 1-2},
  pages={245-53}
}
Although dendritic release was first proposed in the 1970s, the mechanism of release is still subject to debate. We have used in vivo microdialysis to study the acute effects of botulinum toxin A, B and tetanus toxin injected in the substantia nigra or striatum of freely moving rats. Spontaneous and evoked dopamine release decreased in both regions after treatment with the SNAP-25 (synaptosome-associated protein of 25 kDa) cleaving protease botulinum toxin A (1000 mouse lethal doses, MLD… CONTINUE READING