Evidence for differences in the mechanism of cell cycle arrest between senescent and serum-deprived human fibroblasts: heterokaryon and metabolic inhibitor studies.

@article{Burmer1984EvidenceFD,
  title={Evidence for differences in the mechanism of cell cycle arrest between senescent and serum-deprived human fibroblasts: heterokaryon and metabolic inhibitor studies.},
  author={Glenna C. Burmer and Peter S. Rabinovitch and Thomas H. Norwood},
  journal={Journal of cellular physiology},
  year={1984},
  volume={118 1},
  pages={97-103}
}
It has previously been shown that serum-deprived, early passage quiescent human diploid fibroblastlike (HDFL) cells are able to inhibit cycling cells from entry into DNA synthesis upon cell fusion. We have found that the degree of inhibition of DNA synthesis in the heterokaryon correlates with the duration of serum deprivation, which is consistent with the… CONTINUE READING