Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects.

@article{Ulybina2010EvidenceFD,
  title={Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects.},
  author={Yulia M Ulybina and Ekatherina Sh. Kuligina and Nathalia V. Mitiushkina and Nathalia Yu Sherina and Grigoriy A. Yanus and Tatiana V. Gorodnova and Anna S Katanugina and Andrey V. Koloskov and Alexandr V. Togo and Evgeny N. Imyanitov},
  journal={Experimental gerontology},
  year={2010},
  volume={45 9},
  pages={726-9}
}
Our previous studies, which included genotyping of multiple coding apoptotic gene polymorphisms, unexpectedly demonstrated a depletion of heterozygous CASP5 Ala90Thr (rs507879, c.268 G>A) genotypes in elderly subjects. Present investigation was aimed to validate this trend. An analysis of 510 subjects aged 75-103years revealed 205 (40%) CASP5 Ala90Thr heterozygotes as compared to 254 (50%) expected from the minor allele frequency 0.470 (p=0.000014). This deviation was not observed in 549 middle… CONTINUE READING