Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation.

@article{Nieswandt2001EvidenceFC,
  title={Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation.},
  author={Bernhard Nieswandt and Wolfgang Bergmeier and Anita Eckly and Valerie Schulte and Philippe Ohlmann and J. P. Cazenave and Hubert Zirngibl and Stefan Offermanns and Christian Gachet},
  journal={Blood},
  year={2001},
  volume={97 12},
  pages={3829-35}
}
Collagen-induced platelet aggregation is a complex process and involves synergistic action of integrins, immunoglobulin (Ig)-like receptors, G-protein-coupled receptors and their ligands, most importantly collagen itself, thromboxane A(2) (TXA(2)), and adenosine diphosphate (ADP). The precise role of each of these receptor systems in the overall processes of activation and aggregation, however, is still poorly defined. Among the collagen receptors expressed on platelets, glycoprotein (GP) VI… CONTINUE READING