Evidence for corticotropin-releasing factor regulation of serotonin in the lateral septum during acute swim stress: adaptation produced by repeated swimming

@article{Price2002EvidenceFC,
  title={Evidence for corticotropin-releasing factor regulation of serotonin in the lateral septum during acute swim stress: adaptation produced by repeated swimming},
  author={Michelle L. Price and Lynn G. Kirby and Rita J Valentino and Irwin Lucki},
  journal={Psychopharmacology},
  year={2002},
  volume={162},
  pages={406-414}
}
Rationale. Swim stress decreases extracellular serotonin (5-HT) levels in the rat lateral septum, and adaptation to this effect occurs with repeated swimming. Corticotropin-releasing factor (CRF) administered into the dorsal raphe nucleus (DRN) also decreases 5-HT release in the lateral septum, suggesting that CRF may mediate the effects of swim stress. Objectives. The hypothesis that endogenous CRF mediates the reduction of 5-HT levels in the lateral septum evoked by swim stress and is… CONTINUE READING

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